Letters

  • Letter |

    As certain phages can infect some Pseudomonas aeruginosa strains by binding to their pilins, the bacteria have evolved ways to modify these structures via the addition of O-antigen units or polymers of d-arabinofuranose to block phage attachment.

    • Hanjeong Harvey
    • , Joseph Bondy-Denomy
    • , Hélène Marquis
    • , Kristina M. Sztanko
    • , Alan R. Davidson
    •  & Lori L. Burrows
  • Letter |

    To evade autophagy-mediated killing when inside liver cells, the Plasmodium berghei protein UIS3 binds to a key regulator of the autophagy programme, the host protein LC3, and inhibits its interaction with downstream effectors.

    • Eliana Real
    • , Lénia Rodrigues
    • , Ghislain G. Cabal
    • , Francisco J. Enguita
    • , Liliana Mancio-Silva
    • , João Mello-Vieira
    • , Wandy Beatty
    • , Iset M. Vera
    • , Vanessa Zuzarte-Luís
    • , Tiago N. Figueira
    • , Gunnar R. Mair
    •  & Maria M. Mota
  • Letter |

    The cell tropism of noroviruses in vivo remains unclear. Here, the dominant cellular targets during acute norovirus infection of immunocompetent mice are shown to be macrophages, dendritic cells, B cells and T cells in the GALT gut-associated lymphoid tissue.

    • Katrina R. Grau
    • , Alexa N. Roth
    • , Shu Zhu
    • , Abel Hernandez
    • , Natacha Colliou
    • , Bayli B. DiVita
    • , Drake T. Philip
    • , Cara Riffe
    • , Benoit Giasson
    • , Shannon M. Wallet
    • , Mansour Mohamadzadeh
    •  & Stephanie M. Karst
  • Letter |

    Using transcriptome data from marine subsurface sediments, expressed microbial enzymes are shown to be potential targets for secretion by Bacteria, Archaea and Fungi, providing insights into nutrient cycling in the subsurface environment.

    • William D. Orsi
    • , Thomas A. Richards
    •  & Warren R. Francis
  • Letter |

    The crystal structure of MlaA, coupled with simulations of its interaction with phospholipids, elucidates how this outer membrane lipoprotein acts as a phospholipid translocation channel to maintain the asymmetric composition of the outer membrane.

    • Javier Abellón-Ruiz
    • , Shreyas S. Kaptan
    • , Arnaud Baslé
    • , Beatrice Claudi
    • , Dirk Bumann
    • , Ulrich Kleinekathöfer
    •  & Bert van den Berg
  • Letter |

    Structural illumination of host glycan interaction in the evolution and host adaptation of the Salmonella typhoid toxin.

    • Xiang Gao
    • , Lingquan Deng
    • , Gabrielle Stack
    • , Hai Yu
    • , Xi Chen
    • , Yuko Naito-Matsui
    • , Ajit Varki
    •  & Jorge E. Galán
  • Letter |

    In situ sampling reveals that members of the SAR11 clade show significantly lower retention by mucous filter feeders, and that this is probably due to their reduced hydrophobic cell surface, suggesting that cell surface properties are important factors in predator–prey interactions.

    • Ayelet Dadon-Pilosof
    • , Keats R. Conley
    • , Yuval Jacobi
    • , Markus Haber
    • , Fabien Lombard
    • , Kelly R. Sutherland
    • , Laura Steindler
    • , Yaron Tikochinski
    • , Michael Richter
    • , Frank Oliver Glöckner
    • , Marcelino T. Suzuki
    • , Nyree J. West
    • , Amatzia Genin
    •  & Gitai Yahel
  • Letter |

    Reactive oxygen species, most likely spawned from dietary-induced fatty acid β-oxidation, directly impact Plasmodium survival inside hepatocytes and sigificantly reduce liver infection.

    • Vanessa Zuzarte-Luís
    • , João Mello-Vieira
    • , Inês M. Marreiros
    • , Peter Liehl
    • , Ângelo F. Chora
    • , Céline K. Carret
    • , Tânia Carvalho
    •  & Maria M. Mota
  • Letter |

    The structure of the extended sheath–tube complex of the type VI secretion system from Vibrio cholerae elucidates the molecular mechanisms by which conformational changes in the sheath enable the inner tube to penetrate target cells.The structure of the extended sheath–tube complex of the type VI secretion system from Vibrio cholerae elucidates the molecular mechanisms by which conformational changes in the sheath enable the inner tube to penetrate target cells.

    • Jing Wang
    • , Maximilian Brackmann
    • , Daniel Castaño-Díez
    • , Mikhail Kudryashev
    • , Kenneth N. Goldie
    • , Timm Maier
    • , Henning Stahlberg
    •  & Marek Basler
  • Letter |

    Streptococcal para-amino benzoic acid enhances Porphyromonas gingivalis colonization while reducing virulence during polymicrobial oral infection.

    • Masae Kuboniwa
    • , John R. Houser
    • , Erik L. Hendrickson
    • , Qian Wang
    • , Samar A. Alghamdi
    • , Akito Sakanaka
    • , Daniel P. Miller
    • , Justin A. Hutcherson
    • , Tiansong Wang
    • , David A. C. Beck
    • , Marvin Whiteley
    • , Atsuo Amano
    • , Huizhi Wang
    • , Edward M. Marcotte
    • , Murray Hackett
    •  & Richard J. Lamont
  • Letter |

    Infection of the alga Emiliania huxleyi with its virus EhV results in the increased release of extracellular vesicles that impact viral decay and infection, suggesting that EhV exploits these extracellular vesicles for efficient viral infection during algal blooms.

    • Daniella Schatz
    • , Shilo Rosenwasser
    • , Sergey Malitsky
    • , Sharon G. Wolf
    • , Ester Feldmesser
    •  & Assaf Vardi
  • Letter |

    Recombinant proteins based on APOL1 and APOL3 can kill pathogenic Trypanosoma brucei subspecies, including a variant (rPpMUT) that is effective against T.b. gambiense infection in mice, suggesting that it may serve as a therapy against sleeping sickness.

    • Frédéric Fontaine
    • , Laurence Lecordier
    • , Gilles Vanwalleghem
    • , Pierrick Uzureau
    • , Nick Van Reet
    • , Martina Fontaine
    • , Patricia Tebabi
    • , Benoit Vanhollebeke
    • , Philippe Büscher
    • , David Pérez-Morga
    •  & Etienne Pays
  • Letter |

    LysM, the lysis protein of the Escherichia coli levivirus M, represents a new ‘protein antibiotic’ that interferes with the synthesis of peptidoglycan by inhibiting lipid II flipping.

    • Karthik R. Chamakura
    • , Lok-To Sham
    • , Rebecca M. Davis
    • , Lorna Min
    • , Hongbaek Cho
    • , Natividad Ruiz
    • , Thomas G. Bernhardt
    •  & Ry Young
  • Letter |

    Toxoplasma gondii uses its proteins RON2, RON4 and RON5 to recruit host proteins, including the ESCRT-I components ALIX and TSG101 to the moving junction, a multimolecular structure that enables invasion.

    • Amandine Guérin
    • , Rosa Milagros Corrales
    • , Michele L. Parker
    • , Mauld H. Lamarque
    • , Damien Jacot
    • , Hiba El Hajj
    • , Dominique Soldati-Favre
    • , Martin J. Boulanger
    •  & Maryse Lebrun
  • Letter |

    Metagenomic analyses reveal that microbial genomes undergo a community-wide transition in size and GC content across a narrow depth range, indicating that nutrient limitation is a major driver in marine microbial genomic and proteomic evolution.

    • Daniel R. Mende
    • , Jessica A. Bryant
    • , Frank O. Aylward
    • , John M. Eppley
    • , Torben Nielsen
    • , David M. Karl
    •  & Edward F. DeLong
  • Letter |

    Isolation of a cyanophage encoding photosystem I genes reveals that these are expressed during infection and inserted into host membranes, resulting in enhanced electron flow, and that phage carrying these genes are abundant in marine environments.

    • Svetlana Fridman
    • , José Flores-Uribe
    • , Shirley Larom
    • , Onit Alalouf
    • , Oded Liran
    • , Iftach Yacoby
    • , Faris Salama
    • , Benjamin Bailleul
    • , Fabrice Rappaport
    • , Tamar Ziv
    • , Itai Sharon
    • , Francisco M. Cornejo-Castillo
    • , Alon Philosof
    • , Christopher L. Dupont
    • , Pablo Sánchez
    • , Silvia G. Acinas
    • , Forest L. Rohwer
    • , Debbie Lindell
    •  & Oded Béjà
  • Letter |

    A virulent phage of Streptococcus thermophilus encodes an anti-CRISPR protein that is active against the CRISPR–Cas9 of multiple bacteria and inhibits the SpCas9 system commonly used for genome engineering.

    • Alexander P. Hynes
    • , Geneviève M. Rousseau
    • , Marie-Laurence Lemay
    • , Philippe Horvath
    • , Dennis A. Romero
    • , Christophe Fremaux
    •  & Sylvain Moineau
  • Letter |

    Whether phage genetic mosaicism generates a spectrum of diversity or discrete populations is unclear. Two phage evolutionary modes are described here that differ in the extent of horizontal gene transfer depending on host, lifestyle and genetic constitution

    • Travis N. Mavrich
    •  & Graham F. Hatfull
  • Letter |

    This study reports the structure of hRSV NS1, identifying unique regions that modulate host gene expression and contribute to inhibition of the IFN-I pathway and of dendritic cell maturation, pointing to new avenues of hRSV attenuation.

    • Srirupa Chatterjee
    • , Priya Luthra
    • , Ekaterina Esaulova
    • , Eugene Agapov
    • , Benjamin C. Yen
    • , Dominika M. Borek
    • , Megan R. Edwards
    • , Anuradha Mittal
    • , David S. Jordan
    • , Parameshwar Ramanan
    • , Martin L. Moore
    • , Rohit V. Pappu
    • , Michael J. Holtzman
    • , Maxim N. Artyomov
    • , Christopher F. Basler
    • , Gaya K. Amarasinghe
    •  & Daisy W. Leung
  • Letter |

    The undulating surface of mycobacterial cells contains wave troughs inherited from the (grand)mother cell that, combined with chromosome positioning, determine the site where cell division takes place.

    • Haig A. Eskandarian
    • , Pascal D. Odermatt
    • , Joëlle X. Y. Ven
    • , Mélanie T. M. Hannebelle
    • , Adrian P. Nievergelt
    • , Neeraj Dhar
    • , John D. McKinney
    •  & Georg E. Fantner