Browse Articles

  • Editorial |

    Fungal pathogens are virtually ignored by the press, the public and funding bodies, despite posing a significant threat to public health, food biosecurity and biodiversity.

  • News and Views |

    The discovery and genomic characterization of a new group of extreme halophilic methanogens sheds light on the origin of methanogenesis and the evolution of the Haloarchaea.

    • Anja Spang
    •  & Thijs J. G. Ettema
  • News and Views |

    Co-culture of bacterial cells engineered with quorum-sensing and self-lysis circuits allows coupled oscillatory dynamics and stable states, opening the way to engineered microbial ecosystems with targeted dynamics and extending gene circuits to the ecosystem level.

    • Alfonso Jaramillo
  • Article |

    A structural analysis of the C-terminal extension of DotL and its binding partners DotN, IcmS, IcmW and LvgA elucidates how the type IV secretion system (T4SS) of Legionella pneumophila mediates the recruitment of T4SS effectors.

    • Mi-Jeong Kwak
    • , J. Dongun Kim
    • , Hyunmin Kim
    • , Cheolhee Kim
    • , James W. Bowman
    • , Seonghoon Kim
    • , Keehyoung Joo
    • , Jooyoung Lee
    • , Kyeong Sik Jin
    • , Yeon-Gil Kim
    • , Nam Ki Lee
    • , Jae U. Jung
    •  & Byung-Ha Oh
  • Article |

    A lack of models has hindered the study of Ebola virus (EBOV) persistence and sequelae, which are now shown to occur in rhesus monkeys. Progressive EBOV spread into eyes, brain and testes with CD68+ cells as the cryptic EBOV reservoir.

    • Xiankun Zeng
    • , Candace D. Blancett
    • , Keith A. Koistinen
    • , Christopher W. Schellhase
    • , Jeremy J. Bearss
    • , Sheli R. Radoshitzky
    • , Shelley P. Honnold
    • , Taylor B. Chance
    • , Travis K. Warren
    • , Jeffrey W. Froude
    • , Kathleen A. Cashman
    • , John M. Dye
    • , Sina Bavari
    • , Gustavo Palacios
    • , Jens H. Kuhn
    •  & Mei G. Sun
  • Letter |

    Whether phage genetic mosaicism generates a spectrum of diversity or discrete populations is unclear. Two phage evolutionary modes are described here that differ in the extent of horizontal gene transfer depending on host, lifestyle and genetic constitution

    • Travis N. Mavrich
    •  & Graham F. Hatfull
  • Letter |

    This study reports the structure of hRSV NS1, identifying unique regions that modulate host gene expression and contribute to inhibition of the IFN-I pathway and of dendritic cell maturation, pointing to new avenues of hRSV attenuation.

    • Srirupa Chatterjee
    • , Priya Luthra
    • , Ekaterina Esaulova
    • , Eugene Agapov
    • , Benjamin C. Yen
    • , Dominika M. Borek
    • , Megan R. Edwards
    • , Anuradha Mittal
    • , David S. Jordan
    • , Parameshwar Ramanan
    • , Martin L. Moore
    • , Rohit V. Pappu
    • , Michael J. Holtzman
    • , Maxim N. Artyomov
    • , Christopher F. Basler
    • , Gaya K. Amarasinghe
    •  & Daisy W. Leung
  • Article |

    Development of a broad-spectrum β-lactamase inhibitor capable of combatting multidrug-resistant pathogens, including Acinetobacter baumannii.

    • Thomas F. Durand-Réville
    • , Satenig Guler
    • , Janelle Comita-Prevoir
    • , Brendan Chen
    • , Neil Bifulco
    • , Hoan Huynh
    • , Sushmita Lahiri
    • , Adam B. Shapiro
    • , Sarah M. McLeod
    • , Nicole M. Carter
    • , Samir H. Moussa
    • , Camilo Velez-Vega
    • , Nelson B. Olivier
    • , Robert McLaughlin
    • , Ning Gao
    • , Jason Thresher
    • , Tiffany Palmer
    • , Beth Andrews
    • , Robert A. Giacobbe
    • , Joseph V. Newman
    • , David E. Ehmann
    • , Boudewijn de Jonge
    • , John O'Donnell
    • , John P. Mueller
    • , Rubén A. Tommasi
    •  & Alita A. Miller
  • Editorial |

    The WHO's plans to bolster global vector control measures blend audacious goals with a sensible approach that could save lives and stimulate economic growth and development in many of the world's poorest nations.

  • News and Views |

    Nitric oxide synthase has long been associated with control of Mycobacterium tuberculosis infection. However, new work reveals that instead of directing an antibacterial killing response, nitric oxide is critical for restraining granulocytic inflammation, which can provide a nutrient-rich niche for increased bacterial growth.

    • Christina L. Stallings
  • Comment |

    In many countries, the success of misinformation, alternative facts or fake news is promoting a climate of science denial, where false claims such as vaccination causing autism can spread. Learning lessons from behavioural studies can help advocate for vaccination in the face of vaccine refusers and deniers.

    • Cornelia Betsch
  • News and Views |

    Plants respond to microbial attack with a lethal burst of reactive oxygen species. How then, do pathogens successfully invade plants? Unexpectedly, a link between primary metabolism and suppression of plant immunity allows the rice blast fungus Magnaporthe oryzae to grow in such a hostile environment.

    • Antonio Di Pietro
    •  & Nicholas J. Talbot
  • News and Views |

    Coenzymes serve as the catalytic core in many metabolic reactions, but despite their extensive use and intrinsic chemical reactivity, they are remarkably stable.

    • Jens Nielsen
  • Letter |

    The undulating surface of mycobacterial cells contains wave troughs inherited from the (grand)mother cell that, combined with chromosome positioning, determine the site where cell division takes place.

    • Haig A. Eskandarian
    • , Pascal D. Odermatt
    • , Joëlle X. Y. Ven
    • , Mélanie T. M. Hannebelle
    • , Adrian P. Nievergelt
    • , Neeraj Dhar
    • , John D. McKinney
    •  & Georg E. Fantner
  • Letter |

    Metabolic labelling can be used to simultaneously tag peptidoglycan, lipopolysaccharide and capsular polysaccharide of live gut bacteria, and to label peptidoglycan in vivo, revealing host–bacteria interactions within the living mammalian host.

    • Jason E. Hudak
    • , David Alvarez
    • , Ashwin Skelly
    • , Ulrich H. von Andrian
    •  & Dennis L. Kasper
  • Article |

    Structural analysis of the type VI secretion TssK baseplate protein shows structural similarities with phage receptor-binding protein.

    • Van Son Nguyen
    • , Laureen Logger
    • , Silvia Spinelli
    • , Pierre Legrand
    • , Thi Thanh Huyen Pham
    • , Thi Trang Nhung Trinh
    • , Yassine Cherrak
    • , Abdelrahim Zoued
    • , Aline Desmyter
    • , Eric Durand
    • , Alain Roussel
    • , Christine Kellenberger
    • , Eric Cascales
    •  & Christian Cambillau
  • Letter |

    Disruption of a cysteine protease that localizes to the vacuolar compartment of Toxoplasma gondii shows that autophagy is required for the intracellular survival of the parasite during chronic infection.

    • Manlio Di Cristina
    • , Zhicheng Dou
    • , Matteo Lunghi
    • , Geetha Kannan
    • , My-Hang Huynh
    • , Olivia L. McGovern
    • , Tracey L. Schultz
    • , Aric J. Schultz
    • , Alyssa J. Miller
    • , Beth M. Hayes
    • , Wouter van der Linden
    • , Carla Emiliani
    • , Matthew Bogyo
    • , Sébastien Besteiro
    • , Isabelle Coppens
    •  & Vern B. Carruthers
  • Article |

    Cycloclasticus bacterial symbionts of mussels and sponges that live in deep-sea gas and oil seeps are capable of using short-chain alkanes as their primary energy source, providing further insight into chemosynthetic symbioses.

    • Maxim Rubin-Blum
    • , Chakkiath Paul Antony
    • , Christian Borowski
    • , Lizbeth Sayavedra
    • , Thomas Pape
    • , Heiko Sahling
    • , Gerhard Bohrmann
    • , Manuel Kleiner
    • , Molly C. Redmond
    • , David L. Valentine
    •  & Nicole Dubilier
  • Article |

    Sequence-specific interactions between the Hepatitis B virus pre-genome and the core protein define the nucleocapsid assembly pathway and trigger virus-like particle formation. Cp-RNA contacts may regulate pre-genome organization, facilitating reverse transcription.

    • Nikesh Patel
    • , Simon J. White
    • , Rebecca F. Thompson
    • , Richard Bingham
    • , Eva U. Weiß
    • , Daniel P. Maskell
    • , Adam Zlotnick
    • , Eric C. Dykeman
    • , Roman Tuma
    • , Reidun Twarock
    • , Neil A. Ranson
    •  & Peter G. Stockley