Browse Articles

  • Perspective |

    This Perspective describes how lessons learned from traditional probiotics will inform the next generation of probiotics and live biotherapeutic products and the microorganisms suitable for development, and the regulatory framework required to do so.

    • Paul W. O’Toole
    • , Julian R. Marchesi
    •  & Colin Hill
  • Editorial |

    If we are to be successful in keeping priority pathogens at bay in the long term, global responses to antimicrobial resistance should embrace and fund innovative therapeutic strategies that are developed in the basic microbiology laboratory.

  • News and Views |

    Bacterial specialized metabolites are bioactive molecules with antibacterial or other activities that are of tremendous clinical use. New work has revealed that transcript elongation is a distinct and widespread point of secondary metabolic gene regulation, which has implications for expanding drug discovery.

    • Justin R. Nodwell
  • Q&A |

    We spoke with Gary Nabel about research funding, making the move from academia to industry, transformative innovation to improve global health, and the current state of the infectious disease drug pipeline.

    • Nonia Pariente
  • Article |

    Drosophila Bap180 is induced by immune deficiency/Relish in response to both pathogenic and commensal bacteria. Bap180 can feedback to restrain immune deficiency signalling and repress pro-inflammatory gene eiger (TNF), limiting tissue damage and elongating life span.

    • Xiaomeng He
    • , Junjing Yu
    • , Min Wang
    • , Yang Cheng
    • , Yanan Han
    • , Shuo Yang
    • , Guizhi Shi
    • , Lei Sun
    • , Ying Fang
    • , Si-tang Gong
    • , Zhong Wang
    • , Yang-Xin Fu
    • , Lei Pan
    •  & Hong Tang
  • Letter |

    The S-layer structure of C. crescentus is revealed by combining the X-ray crystal structure of an S-layer protein and cryo-ET of cell stalks. The resulting model shows that the S-layer is porous and stabilized by calcium ions.

    • Tanmay A. M. Bharat
    • , Danguole Kureisaite-Ciziene
    • , Gail G. Hardy
    • , Ellen W. Yu
    • , Jessica M. Devant
    • , Wim J. H. Hagen
    • , Yves V. Brun
    • , John A. G. Briggs
    •  & Jan Löwe
  • Letter |

    Single-particle analysis of electron microscopy structures elucidates the mycobacterial ESX-5 type VII secretion system membrane complex.

    • Katherine S. H. Beckham
    • , Luciano Ciccarelli
    • , Catalin M. Bunduc
    • , Haydyn D. T. Mertens
    • , Roy Ummels
    • , Wolfgang Lugmayr
    • , Julia Mayr
    • , Mandy Rettel
    • , Mikhail M. Savitski
    • , Dmitri I. Svergun
    • , Wilbert Bitter
    • , Matthias Wilmanns
    • , Thomas C. Marlovits
    • , Annabel H. A. Parret
    •  & Edith N. G. Houben
  • Letter |

    Diversity-generating retroelements are abundant in the reduced genomes of bacteria and archaea belonging to the CPR and DPANN phyla, driving hypervariability on proteins involved in signalling, transcriptional regulation, attachment and defence.

    • Blair G. Paul
    • , David Burstein
    • , Cindy J. Castelle
    • , Sumit Handa
    • , Diego Arambula
    • , Elizabeth Czornyj
    • , Brian C. Thomas
    • , Partho Ghosh
    • , Jeff F. Miller
    • , Jillian F. Banfield
    •  & David L. Valentine
  • Article |

    Comparative genomics of 24 Penicillium species, including 9 that are newly sequenced, characterizes over 1000 secondary metabolism gene clusters, some of which are validated experimentally, identifying these fungi as an important untapped source of bioactive compounds.

    • Jens Christian Nielsen
    • , Sietske Grijseels
    • , Sylvain Prigent
    • , Boyang Ji
    • , Jacques Dainat
    • , Kristian Fog Nielsen
    • , Jens Christian Frisvad
    • , Mhairi Workman
    •  & Jens Nielsen
  • News and Views |

    Rodent malaria parasites establish chronic infections through the sequential expression of subsets of variant antigen-encoding genes, a process that surprisingly appears to be independent of adaptive immunity.

    • Kirk W. Deitsch
  • Q&A |

    We asked Jill Banfield, a mineralogist-turned-microbiologist, how she became interested in microbial communities, what she thinks about field work, how she manages a multidisciplinary team, and where microbiome studies are headed next.

    • Cláudio Nunes-Alves
  • Perspective |

    Environmental geomicrobial studies offer insights into the structure and function of the built environment microbiome.

    • Geoffrey Michael Gadd
  • Editorial |

    As anti-vaccination movements gain momentum in some regions, World Immunization Week 2017 reminds us that vaccines work and are safe, and that ideological positions contrary to this truth ignore the weight of scientific evidence and deny a long history of lives being saved, endangering many more.

  • News and Views |

    Attaching and effacing enteropathogenic Escherichia coli causes gastrointestinal inflammation and diarrhoea. In this issue of Nature Microbiology, Pearson and colleagues find that this pathology involves bacterial cleavage of a class of host cell death signal adaptors that encode a unique protein interaction motif called the RHIM.

    • Thiago DeSouza-Vieira
    •  & Francis Ka-Ming Chan
  • Perspective |

    Amalgamation of population genetic theory and models of horizontal gene transfer suggest that pangenomes in prokaryotes result from adaptive, not neutral, evolution.

    • James O. McInerney
    • , Alan McNally
    •  & Mary J. O'Connell
  • Article |

    This study shows that mitochondrial DNA leaks into the cytoplasm during dengue virus infection, activating the DNA sensor cGAS. Viral NS2B targets cGAS for lysosomal degradation, inhibiting type I interferon responses in infected cells.

    • Sebastian Aguirre
    • , Priya Luthra
    • , Maria T. Sanchez-Aparicio
    • , Ana M. Maestre
    • , Jenish Patel
    • , Francise Lamothe
    • , Anthony C. Fredericks
    • , Shashank Tripathi
    • , Tongtong Zhu
    • , Jessica Pintado-Silva
    • , Laurence G. Webb
    • , Dabeiba Bernal-Rubio
    • , Alexander Solovyov
    • , Benjamin Greenbaum
    • , Viviana Simon
    • , Christopher F. Basler
    • , Lubbertus C. F. Mulder
    • , Adolfo García-Sastre
    •  & Ana Fernandez-Sesma
  • News and Views |

    The sensor cyclic GMP–AMP synthase (cGAS) is well known to recognize viral DNA. In this issue of Nature Microbiology, infection by dengue virus (DENV), which has an RNA genome, is shown to induce mitochondrial DNA release into the cytosol, leading to cGAS activation. In turn, DENV targets cGAS to evade antiviral immunity.

    • Michiel van Gent
    •  & Michaela U. Gack
  • Letter |

    Crystal structures of the Argonaute protein from the archaeon Methanocaldococcus jannaschii (MjAgo) in its apo state and bound to a guide DNA elucidate the molecular mechanisms that drive DNA-guided DNA silencing in Archaea.

    • Sarah Willkomm
    • , Christine A. Oellig
    • , Adrian Zander
    • , Tobias Restle
    • , Ronan Keegan
    • , Dina Grohmann
    •  & Sabine Schneider
  • Article |

    In addition to canonical guide-dependent endonuclease activity, the Argonaute protein from the archaeon Methanocaldococcus jannaschii (MjAgo) is capable of guide-independent DNA cleavage, enabling MjAgo to process plasmids and genomic DNA.

    • Adrian Zander
    • , Sarah Willkomm
    • , Sapir Ofer
    • , Marleen van Wolferen
    • , Luisa Egert
    • , Sabine Buchmeier
    • , Sarah Stöckl
    • , Philip Tinnefeld
    • , Sabine Schneider
    • , Andreas Klingl
    • , Sonja-Verena Albers
    • , Finn Werner
    •  & Dina Grohmann
  • Article |

    Trypanosoma brucei, which is responsible for human sleeping sickness, has an intrinsic circadian clock that regulates metabolism and influences drug sensitivity.

    • Filipa Rijo-Ferreira
    • , Daniel Pinto-Neves
    • , Nuno L. Barbosa-Morais
    • , Joseph S. Takahashi
    •  & Luisa M. Figueiredo