Allen Cheung & Yiru Huang, HKU

Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection

Latest Research

  • Article |

    A CRISPR–Cas9-based gene drive array platform is developed and combined with mating-competent Candida albicans haploids to generate homozygous double-deletion mutants, transforming our ability to do genetic interaction analyses in fungi.

    • Rebecca S. Shapiro
    • , Alejandro Chavez
    • , Caroline B. M. Porter
    • , Meagan Hamblin
    • , Christian S. Kaas
    • , James E. DiCarlo
    • , Guisheng Zeng
    • , Xiaoli Xu
    • , Alexey V. Revtovich
    • , Natalia V. Kirienko
    • , Yue Wang
    • , George M. Church
    •  & James J. Collins
  • Letter |

    Using transcriptome data from marine subsurface sediments, expressed microbial enzymes are shown to be potential targets for secretion by Bacteria, Archaea and Fungi, providing insights into nutrient cycling in the subsurface environment.

    • William D. Orsi
    • , Thomas A. Richards
    •  & Warren R. Francis
  • Letter |

    The crystal structure of MlaA, coupled with simulations of its interaction with phospholipids, elucidates how this outer membrane lipoprotein acts as a phospholipid translocation channel to maintain the asymmetric composition of the outer membrane.

    • Javier Abellón-Ruiz
    • , Shreyas S. Kaptan
    • , Arnaud Baslé
    • , Beatrice Claudi
    • , Dirk Bumann
    • , Ulrich Kleinekathöfer
    •  & Bert van den Berg
  • Article |

    Bacillus subtilis cells are able to sense self-produced autoinducers, which gives rise to stronger quorum-sensing-mediated responses, in a process that can influence the generation of persisters during antibiotic treatment.

    • Tasneem Bareia
    • , Shaul Pollak
    •  & Avigdor Eldar
  • Letter |

    Structural illumination of host glycan interaction in the evolution and host adaptation of the Salmonella typhoid toxin.

    • Xiang Gao
    • , Lingquan Deng
    • , Gabrielle Stack
    • , Hai Yu
    • , Xi Chen
    • , Yuko Naito-Matsui
    • , Ajit Varki
    •  & Jorge E. Galán
  • Article |

    Comparative genomics and high-resolution mass spectrometry reveal the biosynthetic gene clusters, and vast chemical diversity of natural products that they encode, in Photorhabdus and Xenorhabdus, bacteria that interact with hosts as symbionts and entomopathogens.

    • Nicholas J. Tobias
    • , Hendrik Wolff
    • , Bardya Djahanschiri
    • , Florian Grundmann
    • , Max Kronenwerth
    • , Yi-Ming Shi
    • , Svenja Simonyi
    • , Peter Grün
    • , David Shapiro-Ilan
    • , Sacha J. Pidot
    • , Timothy P. Stinear
    • , Ingo Ebersberger
    •  & Helge B. Bode

News & Comment

  • News and Views |

    The study of phages that pose a threat to the cheese industry, which enabled the original demonstration that CRISPR–Cas systems work as adaptive immune systems in bacteria, now leads to the identification of a new anti-CRISPR that inhibits Cas9 from Streptococcus pyogenes.

    • Alan R. Davidson
  • Editorial |

    Translating scientific discoveries into real world solutions is a goal shared by researchers, governments, industry and the public alike. While continued support for basic research is critical, improvements in the funding, evaluation and publication of translational work are also needed to fully realize the promise of applied research.

  • News and Views |

    The Streptococcus pyogenes surface M protein is a critical multifunctional virulence factor. Recent work sheds light on a new unexpected function of the M protein in activating the host inflammasome to induce macrophage cell death and promote infection.

    • Madeleine W. Cunningham
  • News and Views |

    The goal of malaria eradication is threatened by drug resistance. Now, two studies characterize Plasmodium falciparum PKG inhibitors and hexahydroquinolines as antimalarial compounds that could block transmission and help mitigate the risk of parasite escape via drug resistance.

    • Thierry Diagana
    •  & Catherine Jones
  • News and Views |

    Influenza B virus causes substantial illness globally, particularly in children. Treatment options are limited, as the most widely used antiviral drug appears to be less effective than against influenza A. A new antibody targeting the influenza B neuraminidase shows promise in mice as a therapeutic option.

    • Aeron C. Hurt
    •  & Kanta Subbarao
  • News and Views |

    A newly described plasmid, which encodes proteins facilitating its packaging and cell-to-cell transfer via membrane vesicles, challenges the way we think about the delineation of viruses, plasmids and extracellular vesicles.

    • Patrick Forterre
    • , Violette Da Cunha
    •  & Ryan Catchpole

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