D. Perez-Morga and the Université Libre de Bruxelles

APOLs with low pH dependence can kill all African trypanosomes

Latest Research

  • Letter |

    As certain phages can infect some Pseudomonas aeruginosa strains by binding to their pilins, the bacteria have evolved ways to modify these structures via the addition of O-antigen units or polymers of d-arabinofuranose to block phage attachment.

    • Hanjeong Harvey
    • , Joseph Bondy-Denomy
    • , Hélène Marquis
    • , Kristina M. Sztanko
    • , Alan R. Davidson
    •  & Lori L. Burrows
  • Article |

    How the oral epithelium discriminates pathogens from commensals is unclear. Ephrin A2 is now shown to bind exposed β-glucans on the surface of the fungal pathogen Candida albicans, which is required to mount a proinflammatory and antifungal response.

    • Marc Swidergall
    • , Norma V. Solis
    • , Michail S. Lionakis
    •  & Scott G. Filler
  • Letter |

    To evade autophagy-mediated killing when inside liver cells, the Plasmodium berghei protein UIS3 binds to a key regulator of the autophagy programme, the host protein LC3, and inhibits its interaction with downstream effectors.

    • Eliana Real
    • , Lénia Rodrigues
    • , Ghislain G. Cabal
    • , Francisco J. Enguita
    • , Liliana Mancio-Silva
    • , João Mello-Vieira
    • , Wandy Beatty
    • , Iset M. Vera
    • , Vanessa Zuzarte-Luís
    • , Tiago N. Figueira
    • , Gunnar R. Mair
    •  & Maria M. Mota
  • Article | | open

    Cultivation of a cellulolytic consortium reveals successional community dynamics and the presence of multidomain glycoside hydrolases assembled into stable complexes distinct from cellulosomes, which are produced by a potential pioneer population.

    • Sebastian Kolinko
    • , Yu-Wei Wu
    • , Firehiwot Tachea
    • , Evelyn Denzel
    • , Jennifer Hiras
    • , Raphael Gabriel
    • , Nora Bäcker
    • , Leanne Jade G. Chan
    • , Stephanie A. Eichorst
    • , Dario Frey
    • , Qiushi Chen
    • , Parastoo Azadi
    • , Paul D. Adams
    • , Todd R. Pray
    • , Deepti Tanjore
    • , Christopher J. Petzold
    • , John M. Gladden
    • , Blake A. Simmons
    •  & Steven W. Singer
  • Article |

    This study reports the viral and cellular N 6-methyladenosine (m6A) and N 6,2′-O-dimethyladenosine (m6Am) epitranscriptomes during KSHV latent and lytic infection, and shows that lytic replication induces dynamic epitranscriptome reprogramming of host pathways that control this process.

    • Brandon Tan
    • , Hui Liu
    • , Songyao Zhang
    • , Suzane Ramos da Silva
    • , Lin Zhang
    • , Jia Meng
    • , Xiaodong Cui
    • , Hongfeng Yuan
    • , Océane Sorel
    • , Shao-Wu Zhang
    • , Yufei Huang
    •  & Shou-Jiang Gao

News & Comment

  • News and Views |

    The Uncultivated Bacteria and Archaea dataset is a foundational collection of 7,903 genomes from uncultivated microorganisms. It highlights how microbial diversity is readily recovered using current tools and existing metagenomic datasets to help piece together the tree of life.

    • Lindsey M. Solden
    •  & Kelly C. Wrighton
  • Editorial |

    An increased focus on identifying disease hotspots and pre-emptive intervention will be key to halting outbreaks before they become established, but political and economic obstacles cannot be ignored if ambitious new targets to reduce global cholera mortality tenfold are to be achieved.

  • News and Views |

    Two studies identify circulating monocytes as the primary cellular target of Zika virus infection in human blood. Monocytes are an ideal target as they have the potential to be used as a Trojan horse to infiltrate immune-sheltered tissues, including placenta, testes and the brain, to spread Zika virus.

    • Kellie Ann Jurado
    •  & Akiko Iwasaki
  • News and Views |

    The study of phages that pose a threat to the cheese industry, which enabled the original demonstration that CRISPR–Cas systems work as adaptive immune systems in bacteria, now leads to the identification of a new anti-CRISPR that inhibits Cas9 from Streptococcus pyogenes.

    • Alan R. Davidson
  • Editorial |

    Translating scientific discoveries into real world solutions is a goal shared by researchers, governments, industry and the public alike. While continued support for basic research is critical, improvements in the funding, evaluation and publication of translational work are also needed to fully realize the promise of applied research.

  • News and Views |

    The Streptococcus pyogenes surface M protein is a critical multifunctional virulence factor. Recent work sheds light on a new unexpected function of the M protein in activating the host inflammasome to induce macrophage cell death and promote infection.

    • Madeleine W. Cunningham

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