Kyle Mohler

Translational fidelity and mistranslation in the cellular response to stress

Latest Research

  • Letter |

    Streptococcal para-amino benzoic acid enhances Porphyromonas gingivalis colonization while reducing virulence during polymicrobial oral infection.

    • Masae Kuboniwa
    • , John R. Houser
    • , Erik L. Hendrickson
    • , Qian Wang
    • , Samar A. Alghamdi
    • , Akito Sakanaka
    • , Daniel P. Miller
    • , Justin A. Hutcherson
    • , Tiansong Wang
    • , David A. C. Beck
    • , Marvin Whiteley
    • , Atsuo Amano
    • , Huizhi Wang
    • , Edward M. Marcotte
    • , Murray Hackett
    •  & Richard J. Lamont
  • Letter |

    Infection of the alga Emiliania huxleyi with its virus EhV results in the increased release of extracellular vesicles that impact viral decay and infection, suggesting that EhV exploits these extracellular vesicles for efficient viral infection during algal blooms.

    • Daniella Schatz
    • , Shilo Rosenwasser
    • , Sergey Malitsky
    • , Sharon G. Wolf
    • , Ester Feldmesser
    •  & Assaf Vardi
  • Letter |

    Recombinant proteins based on APOL1 and APOL3 can kill pathogenic Trypanosoma brucei subspecies, including a variant (rPpMUT) that is effective against T.b. gambiense infection in mice, suggesting that it may serve as a therapy against sleeping sickness.

    • Frédéric Fontaine
    • , Laurence Lecordier
    • , Gilles Vanwalleghem
    • , Pierrick Uzureau
    • , Nick Van Reet
    • , Martina Fontaine
    • , Patricia Tebabi
    • , Benoit Vanhollebeke
    • , Philippe Büscher
    • , David Pérez-Morga
    •  & Etienne Pays
  • Article | | open

    The recovery of 7,903 bacterial and archaeal metagenome-assembled genomes increases the phylogenetic diversity represented by public genome repositories and provides the first representatives from 20 candidate phyla.

    • Donovan H. Parks
    • , Christian Rinke
    • , Maria Chuvochina
    • , Pierre-Alain Chaumeil
    • , Ben J. Woodcroft
    • , Paul N. Evans
    • , Philip Hugenholtz
    •  & Gene W. Tyson
  • Article |

    The structures of a variant surface glycoprotein (VSG) from Trypanosoma brucei suggest that VSGs adopt different conformations to respond to obstacles present in the cell membrane, enabling them to maintain a protective coat at all times.

    • Thomas Bartossek
    • , Nicola G. Jones
    • , Christin Schäfer
    • , Mislav Cvitković
    • , Marius Glogger
    • , Helen R. Mott
    • , Jochen Kuper
    • , Martha Brennich
    • , Mark Carrington
    • , Ana-Sunčana Smith
    • , Susanne Fenz
    • , Caroline Kisker
    •  & Markus Engstler
  • Letter |

    LysM, the lysis protein of the Escherichia coli levivirus M, represents a new ‘protein antibiotic’ that interferes with the synthesis of peptidoglycan by inhibiting lipid II flipping.

    • Karthik R. Chamakura
    • , Lok-To Sham
    • , Rebecca M. Davis
    • , Lorna Min
    • , Hongbaek Cho
    • , Natividad Ruiz
    • , Thomas G. Bernhardt
    •  & Ry Young

News & Comment

  • News and Views |

    The 2013–2016 West African Ebola virus outbreak evidenced that the virus can persist in survivors long-term, leading to sequelae and risks of new transmission chains. Ebola virus has now been shown to behave similarly in rhesus macaques, enabling their use to study persistence and intervention strategies.

    • Trina Racine
    •  & Gary P. Kobinger
  • News and Views |

    Structural analyses of the type IV coupling protein of the Dot/Icm type IV secretion system from Legionella pneumophila reveal how this platform recruits a plethora of substrates for translocation.

    • Peter J. Christie
  • News and Views |

    Proteomics analyses reveal how the long-term coexistence of the marine picocyanobacterium Synechococcus and the heterotroph Ruegeria pomeroyi, of the globally abundant marine Roseobacter group, is based on the mutual and beneficial recycling of inorganic and organic nitrogen compounds.

    • Meinhard Simon
  • Editorial |

    The recommendation that antibiotic courses are always completed should be dropped according to a recent analysis. While a welcome addition to discussion on the role of stewardship in tackling resistance, caution should be applied before advice on prescription practices and communication with patients is altered.

  • Editorial |

    Fungal pathogens are virtually ignored by the press, the public and funding bodies, despite posing a significant threat to public health, food biosecurity and biodiversity.

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