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Close encounters: integrating nanopores and CMOS amplifiers for single-molecule detection

Using semiconductor processing to construct integrated circuits that reside close to nanopores, researchers demonstrate high-bandwidth, low-noise measurements of DNA translocation through solid-state nanopores.

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Figure 1: Schematic of a resistive pulse measurement of DNA translocation through a solid-state nanopore.

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Correspondence to John S Oliver.

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J.S.O. and V.D. are employees of Nabsys Inc.

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Oliver, J., Dimitrov, V. Close encounters: integrating nanopores and CMOS amplifiers for single-molecule detection. Nat Methods 9, 453–454 (2012). https://doi.org/10.1038/nmeth.1981

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