In living systems, chemical reactions and the geometry of cells feed back on each other. Methods for computational modeling are beginning to take this complexity into account.
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Sneddon, M., Emonet, T. Modeling cellular signaling: taking space into the computation. Nat Methods 9, 239–242 (2012). https://doi.org/10.1038/nmeth.1900
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DOI: https://doi.org/10.1038/nmeth.1900
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