Wisedchaisri, G. & Gonen, T. Structure 19, 976–987 (2011).

Electron crystallography is a powerful method for obtaining structural information about membrane proteins from two-dimensional crystals. A challenge, however, is collecting image data that can provide experimental phase information to solve structures at high resolution. Wisedchaisri and Gonen describe a way around this by obtaining phase information from low-resolution images using a fragment-based phase-extension method. This allowed them to solve the high-resolution structures of aquaporin-4, bacteriorhodopsin and aquaporin-0.