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Volume 8 Issue 4, April 2011

The cover image artistically depicts the isolation and analysis of a single cell from within a heterogeneous cellular population. Cover design by Erin Dewalt. Supplement Foreword p307

Editorial

  • Meeting organizers and speakers are increasingly open to blogging and microblogging—an encouraging trend that should be expanded with clearly defined restrictions.

    Editorial

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This Month

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Correspondence

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Research Highlights

  • Two recent reports demonstrate the first applications of X-ray free-electron lasers to look at biological structures.

    • Allison Doerr
    Research Highlights
  • Illuminating cells through tiny transparent pillars permits spatially confined excitation of fluorescent molecules.

    • Natalie de Souza
    Research Highlights
  • Researchers use light-activated photo-uncaging to dissect the elementary steps in protein kinase signaling networks in living human cells.

    • Allison Doerr
    Research Highlights
  • Reference datasets of gene expression and DNA methylation in human pluripotent stem cell lines are reported.

    • Natalie de Souza
    Research Highlights
  • An image-analysis technique deconvolutes combinations of labels, revealing which bacteria are where in microbial communities.

    • Monya Baker
    Research Highlights
  • A digital platform has been created to incorporate multiple brain data resources into a common global mouse atlas.

    • Erika Pastrana
    Research Highlights
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Technology Feature

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News & Views

  • A wearable imaging device allows functional whole-brain imaging of awake, freely moving rats. This technology opens up a noninvasive window for simultaneously assessing brain function and behavior in response to a wide variety of interventions in living rats.

    • Simon R Cherry
    News & Views
  • Two fluorescence microscopy techniques provide alternative routes to obtaining three-dimensional super-resolution images with greater axial depth.

    • Bo Huang
    News & Views
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Foreword

    • Natalie de Souza
    Foreword
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Summaries

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Commentary

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Brief Communication

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Article

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Advertising Feature: Application Note

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