Assemblies: the good, the bad, the ugly

Journal name:
Nature Methods
Volume:
8,
Pages:
59–60
Year published:
DOI:
doi:10.1038/nmeth0111-59
Published online

The low cost of short-read sequencing has motivated the development of de novo assemblies from only short-read data; impressively, assemblies for large mammalian genomes are now available. However, this is still a developing field, and these de novo assemblies have many artifacts, as do all de novo assemblies.

References

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Affiliations

  1. Ewan Birney is at the European Molecular Biology Laboratory–European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.

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The author declares no competing financial interests.

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