Brief Communication abstract
Nature Methods 6, 663 - 666 (2009)
Published online: 9 August 2009 | doi:10.1038/nmeth.1359
A customized and versatile high-density genotyping array for the mouse
Hyuna Yang1, Yueming Ding1, Lucie N Hutchins1, Jin Szatkiewicz1, Timothy A Bell2, Beverly J Paigen1, Joel H Graber1, Fernando Pardo-Manuel de Villena2 & Gary A Churchill1
We designed a high-density mouse genotyping array containing 623,124 single-nucleotide polymorphisms that captures the known genetic variation present in the laboratory mouse. The array also contains 916,269 invariant genomic probes targeted to functional elements and regions known to harbor segmental duplications. The array opens the door to the characterization of genetic diversity, copy-number variation, allele-specific gene expression and DNA methylation, and will extend the successes of human genome-wide association studies to the mouse.
- The Jackson Laboratory, Bar Harbor, Maine, USA.
- Department of Genetics, University of North Carolina–Chapel Hill, Chapel Hill, North Carolina, USA.
Correspondence to: Gary A Churchill1 e-mail: gary.churchill@jax.org
Correspondence to: Fernando Pardo-Manuel de Villena2 e-mail: fernando@med.unc.edu
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