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Brief Communication

Nature Methods 6, 507–510 (1 July 2009) | doi:10.1038/nmeth.1343

Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection

Daniel S Herman , G Kees Hovingh , Oleg Iartchouk , Heidi L Rehm , Raju Kucherlapati , J G Seidman & Christine E Seidman

To exploit contemporary sequencing technologies for targeted genetic analyses, we developed a hybridization enrichment strategy for DNA capture that uses PCR products as subgenomic traps. We applied this strategy to 115 kilobases of the human genome encompassing 47 genes implicated in cardiovascular disease.