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Downhill protein folding under pressure

Sub-microsecond, downhill-reaction protein folding can be investigated by a method to generate large and fast pressure drops. The approach is complementary to nanosecond temperature-jump methods and could provide new insights into the biophysics of protein folding.

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Figure 1: Depiction of the sub-microsecond pressure-drop experiments of Gruebele and co-workers2.

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Muñoz, V. Downhill protein folding under pressure. Nat Methods 6, 490–491 (2009). https://doi.org/10.1038/nmeth0709-490

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