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Correspondence
Nature Methods 6, 476–477 (1 July 2009) | doi:10.1038/nmeth0709-476
RNAiCut: automated detection of significant genes from functional genomic screens
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Abstract
To the Editor: RNA interference (RNAi) is a popular functional genomic technology for identifying genes involved in a biological process. Although higher scores for genes in an RNAi screen suggest more central roles in the pathway, estimating the score threshold separating pathway- or process-relevant hits from noise remains difficult (Supplementary Table 1) and is typically done manually.
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