Table of contents
ARTICLE NAVIGATION - ISSUE
Supplement
Next-generation sequencing data analysis
- Supplement issue:
- November 2009 Volume 6, No 11
A commissioned Commentary discusses the strength and challenges of next-generation sequencing, and a series of commissioned Reviews explain the principles behind data-analysis software for important applications from alignment and assembly to structural-variant detection and the interpretation of ChIP-seq and RNA-seq data.
Foreword
Focus on next-generation sequencing data analysis - pS1
Nicole Rusk
doi:10.1038/nmeth.f.271
Full Text - Focus on next-generation sequencing data analysis | PDF (146 KB) - Focus on next-generation sequencing data analysis
Commentary
Next-generation gap - ppS2 - S5
John D McPherson
doi:10.1038/nmeth.f.268
Abstract - Next-generation gap | Full Text - Next-generation gap | PDF (558 KB) - Next-generation gap
Reviews
Sense from sequence reads: methods for alignment and assembly - ppS6 - S12
Paul Flicek & Ewan Birney
doi:10.1038/nmeth.1376
Abstract - Sense from sequence reads: methods for alignment and assembly | Full Text - Sense from sequence reads: methods for alignment and assembly | PDF (442 KB) - Sense from sequence reads: methods for alignment and assembly
Computational methods for discovering structural variation with next-generation sequencing - ppS13 - S20
Paul Medvedev, Monica Stanciu & Michael Brudno
doi:10.1038/nmeth.1374
Abstract - Computational methods for discovering structural variation with next-generation sequencing | Full Text - Computational methods for discovering structural variation with next-generation sequencing | PDF (490 KB) - Computational methods for discovering structural variation with next-generation sequencing
Computation for ChIP-seq and RNA-seq studies - ppS22 - S32
Shirley Pepke, Barbara Wold & Ali Mortazavi
doi:10.1038/nmeth.1371
Abstract - Computation for ChIP-seq and RNA-seq studies | Full Text - Computation for ChIP-seq and RNA-seq studies | PDF (1,014 KB) - Computation for ChIP-seq and RNA-seq studies
