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Inhibiting microRNA function in vivo

A new strategy is presented to functionally knock down microRNAs in a mouse.

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Figure 1: The predicted biogenesis of a miRNA and its functional knock-down in vivo by an miRNA inhibitor encoded in a stably integrated lentiviral vector.

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Medina, P., Slack, F. Inhibiting microRNA function in vivo. Nat Methods 6, 37–38 (2009). https://doi.org/10.1038/nmeth0109-37

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