Brief Communication abstract


Nature Methods 6, 75 - 77 (2009)
Published online: 14 December 2008 | doi:10.1038/nmeth.1282

Integrated network analysis platform for protein-protein interactions

Jianmin Wu1, Tea Vallenius1,4, Kristian Ovaska1,4, Jukka Westermarck2,3, Tomi P Mäkelä1 & Sampsa Hautaniemi1

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There is an increasing demand for network analysis of protein-protein interactions (PPIs). We introduce a web-based protein interaction network analysis platform (PINA), which integrates PPI data from six databases and provides network construction, filtering, analysis and visualization tools. We demonstrated the advantages of PINA by analyzing two human PPI networks; our results suggested a link between LKB1 and TGFβ signaling, and revealed possible competitive interactors of p53 and c-Jun.

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  1. Genome-Scale Biology Program, Institute of Biomedicine, University of Helsinki, Haartmaninkatu 8, Helsinki 00014, Finland.
  2. Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 8, Tampere 33520, Finland.
  3. Centre for Biotechnology, University of Turku and Åbo Akademi University, Tykistökatu 6A, Turku 23520, Finland.
  4. These authors contributed equally to this work.

Correspondence to: Jianmin Wu1 e-mail: jianmin.wu@helsinki.fi



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