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Nature Methods 5, 759 - 760 (2008)
doi:10.1038/nmeth0908-759
Sex to the rescue
Thomas J Silhavy1 & Zemer Gitai1
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Thomas J. Silhavy and Zemer Gitai are in the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
e-mail: tsilhavy@princeton.edu
Abstract
Applying a classical solution to a cutting-edge problem, two groups used bacterial conjugation to construct Escherichia coli double mutants on a genome-wide scale. This will allow comprehensive genetic interaction screens in bacteria for the first time.
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RESEARCH
High-throughput, quantitative analyses of genetic interactions in E. coliNature Methods Article (01 Sep 2008)
