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Nature Methods 5, 585–587 (1 July 2008) | doi:10.1038/nmeth0708-585

The beginning of the end for microarrays?

Jay Shendure

For over a decade, DNA microarrays have provided a powerful approach to achieve parallel interrogation of biological systems at a genomic scale. But two new reports in this issue of Nature Methods demonstrate that massively parallel DNA sequencing may be on its way to supplanting microarrays as the technology of choice for quantifying and annotating transcriptomes.