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Nature Methods 5, 385–387 (1 May 2008) | doi:10.1038/nmeth0508-385

Super-resolution light microscopy goes live

Mats G L Gustafsson

The laws of diffraction set a fundamental limit to the spatial resolution of the conventional light microscope. The long-standing dream of doing away with this limit has been partly realized in recent years through various forms of super-resolution microscopy.