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Nature Methods 5, 384–385 (1 May 2008) | doi:10.1038/nmeth0508-384

Metastasis: two assays explore the two roads traveled

Diane Renee Bielenberg

Metastasis—the spread of tumor cells from the primary site to distant organs—is the leading cause of death from cancer. Tumor cells disseminate through two main routes, blood vessels and lymphatic vessels (Fig.