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Brief Communication
Nature Methods 5, 231–233 (1 March 2008) | doi:10.1038/nmeth.1182
Generating somatic mosaicism with a Cre recombinase|[ndash]|microsatellite sequence transgene
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Abstract
Strategies for altering constitutional or somatic genotype in mice are well established, but approaches to generate mosaic genotypes in mouse tissues are limited. We showed that a functionally inactive Cre recombinase transgene with a long mononucleotide tract altering the reading frame was stochastically activated in the mouse intestinal tract.
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