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Brief Communication

Nature Methods 5, 239–241 (1 March 2008) | doi:10.1038/nmeth.1181

A systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae

Grace Marie Jones , Jim Stalker , Sean Humphray , Anthony West , Tony Cox , Jane Rogers , Ian Dunham & Gregory Prelich

Modern genetic analysis requires the development of new resources to systematically explore gene function in vivo. Overexpression screens are a powerful method to investigate genetic pathways, but the goal of routine and comprehensive overexpression screens has been hampered by the lack of systematic libraries.