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Brief Communication

Nature Methods 5, 171–173 (1 February 2008) | doi:10.1038/nmeth.1177

A secreted luciferase for ex vivo monitoring of in vivo processes

Thomas Wurdinger , Christian Badr , Lisa Pike , Ruben de Kleine , Ralph Weissleder , Xandra O Breakefield & Bakhos A Tannous

Luciferases are widely used to monitor biological processes. Here we describe the naturally secreted Gaussia princeps luciferase (Gluc) as a highly sensitive reporter for quantitative assessment of cells in vivo by measuring its concentration in blood.