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Brief Communication
Nature Methods 5, 179–181 (1 February 2008) | doi:10.1038/nmeth.1172
Pyrobayes: an improved base caller for SNP discovery in pyrosequences
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Abstract
Previously reported applications of the 454 Life Sciences pyrosequencing technology have relied on deep sequence coverage for accurate polymorphism discovery because of frequent insertion and deletion sequence errors. Here we report a new base calling program, Pyrobayes, for pyrosequencing reads.
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