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Brief Communication

Nature Methods 5, 935–938 (1 November 2008) | doi:10.1038/nmeth.1256

High-speed, miniaturized fluorescence microscopy in freely moving mice

Benjamin A Flusberg , Axel Nimmerjahn , Eric D Cocker , Eran A Mukamel , Robert P J Barretto , Tony H Ko , Laurie D Burns , Juergen C Jung & Mark J Schnitzer

A central goal in biomedicine is to explain organismic behavior in terms of causal cellular processes. However, concurrent observation of mammalian behavior and underlying cellular dynamics has been a longstanding challenge.