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Nature Methods 5, 863–864 (1 October 2008) | doi:10.1038/nmeth1008-863

Classical genetics goes high-tech

David S Fay

Even the most ardent practitioners of classical genetics in metazoan organisms such as worms and flies will admit, in moments of weakness, that their fields have a well-deserved bad rap for harboring experimental bottlenecks. This is particularly true of the monumental efforts often involved in isolating mutants and uncovering their molecular identities.