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Brief Communication

Nature Methods 5, 865–867 (1 October 2008) | doi:10.1038/nmeth.1249

Caenorhabditis elegans mutant allele identification by whole-genome sequencing

Sumeet Sarin , Snehit Prabhu , M Maggie O'Meara , Itsik Pe'er & Oliver Hobert

Identification of the molecular lesion in Caenorhabditis elegans mutants isolated through forward genetic screens usually involves time-consuming genetic mapping. We used Illumina deep sequencing technology to sequence a complete, mutant C.