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Nature Methods - 5, 16 - 18 (2008)
Published online: 19 December 2007; | doi:10.1038/nmeth1156

Next-generation sequencing transforms today's biology

Stephan C Schuster

Stephan C. Schuster is at Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA. scs@bx.psu.edu

A new generation of non-Sanger-based sequencing technologies has delivered on its promise of sequencing DNA at unprecedented speed, thereby enabling impressive scientific achievements and novel biological applications. However, before stepping into the limelight, next-generation sequencing had to overcome the inertia of a field that relied on Sanger-sequencing for 30 years.

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Nature Methods
ISSN: 1548-7091
EISSN: 1548-7105
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