 | Figure 1
Nature Methods
- 4, 684 - 685 (2007)
doi:10.1038/nmeth0907-684a
Gene regulation Switching genes off—all the wayNicole Rusk | | | | Figure 1. A synthetic gene network.
In the off state the Lac repressor is expressed and inhibits the Tet repressor (tetR) as well as the gene of interest (GOI). shRNA prevents any residual gene expression. In the on state, a drug inhibits lacI expression, resulting in expression of the GOI and the Tet repressor, which inhibits the shRNA.
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