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Artistic interpretation of high-resolution Drosophila polytene chromosome spreads by Erin Boyle, based on images provided by Dmitri Novikov. High-resolution light microscopic images were obtained by using precision devices to spread the chromosomes. Article p483
A new mass spectrometry (MS) approach has been developed, allowing combinatorial analysis of histone H3.2 post-translational modifications that may provide the key to unlocking the histone code.
High-throughput screening, traditionally the domain of big pharmaceutical companies, is now creeping into academic laboratories in the guise of chemical genomics. Though the technique can be demanding and expensive, it is already yielding impressive results, as Alan Dove finds out.