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Brief Communication
Nature Methods 4, 405–407 (1 May 2007) | doi:10.1038/nmeth1042
A yeast two-hybrid smart-pool-array system for protein-interaction mapping
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Abstract
We present here a new two-hybrid smart pool array (SPA) system in which, instead of individual activation domain strains, well-designed activation domain pools are screened in an array format that allows built-in replication and prey-bait deconvolution. Using this method, a Saccharomyces cerevisiae genome SPA increases yeast two-hybrid screening efficiency by an order of magnitude.
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