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Quantized plasmon quenching dips nanospectroscopy via plasmon resonance energy transfer

Nature Methods volume 4, pages 1015–1017 (2007)Cite this article

Abstract

We observed quantized plasmon quenching dips in resonant Rayleigh scattering spectra by plasmon resonance energy transfer (PRET) from a single nanoplasmonic particle to adsorbed biomolecules. This label-free biomolecular absorption nanospectroscopic method has ultrahigh molecular sensitivity.

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Figure 1: Schematic diagrams of quantized plasmon quenching dips nanospectroscopy via PRET.
Figure 2: Experimental results of PRET from single gold nanoparticle to conjugated cytochrome c molecules.
Figure 3: The PRET spectra for three representative gold nanoparticles conjugated with reduced cytochrome c molecules.

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Acknowledgements

This work was supported by a grant (05K1501-02810) from 'Center for Nanostructured Materials Technology' under '21st Century Frontier R&D Programs' of the Ministry of Science and Technology, Korea.

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Author notes

  1. Present address: Center for Micro and Nano Technology, Lawrence Livermore National Laboratory, P.O. Box 808, L-223, Livermore, California 94551, USA.

  2. Gang Logan Liu and Yi-Tao Long: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Bioengineering, Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, University of California-Berkeley, 442 Stanley Hall, Berkeley, 94720, California, USA

    Yi-Tao Long, Yeonho Choi, Taewook Kang & Luke P Lee

  2. Joint Graduate Group in Bioengineering, University of California at San Francisco and Berkeley, 1700 4th Street, San Francisco, 94158, California, USA

    Luke P Lee

Authors
  1. Gang Logan Liu
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  2. Yi-Tao Long
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  3. Yeonho Choi
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  4. Taewook Kang
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  5. Luke P Lee
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Contributions

G.L.L. discovered the new finding, conceived the idea and performed the measurements, Y.-T.L. conceived the idea, initiated the experiment, performed the measurements and processed the data, Y.C. repeated the experiments and designed additional experiments, T.K. improved the conjugation chemistry and repeated the experiments, and L.P.L. conceived the idea, designed the experiments and advised other authors.

Corresponding author

Correspondence to Luke P Lee.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–4, Supplementary Methods (PDF 1176 kb)

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Liu, G., Long, YT., Choi, Y. et al. Quantized plasmon quenching dips nanospectroscopy via plasmon resonance energy transfer. Nat Methods 4, 1015–1017 (2007). https://doi.org/10.1038/nmeth1133

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