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Brief Communication
Nature Methods - 4, 1015 - 1017 (2007)
Published online: 18 November 2007; | doi:10.1038/nmeth1133

Quantized plasmon quenching dips nanospectroscopy via plasmon resonance energy transfer

Gang Logan Liu4, Yi-Tao Long1, 4, Yeonho Choi1, Taewook Kang1 & Luke P Lee1, 2

1  Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California-Berkeley, 442 Stanley Hall, Berkeley, California 94720, USA.

2  Joint Graduate Group in Bioengineering, University of California at San Francisco and Berkeley, 1700 4th Street, San Francisco, California 94158, USA.

3  Present address: Center for Micro and Nano Technology, Lawrence Livermore National Laboratory, P.O. Box 808, L-223, Livermore, California 94551, USA.

4  These authors contributed equally to this work.

Correspondence should be addressed to Luke P Lee lplee@berkeley.edu

We observed quantized plasmon quenching dips in resonant Rayleigh scattering spectra by plasmon resonance energy transfer (PRET) from a single nanoplasmonic particle to adsorbed biomolecules. This label-free biomolecular absorption nanospectroscopic method has ultrahigh molecular sensitivity.

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Nature Methods
ISSN: 1548-7091
EISSN: 1548-7105
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