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Volume 4 Issue 11, November 2007

Specific genomic enrichment methods, represented by Erin Boyle, based on an idea by Thomas Albert. The image of DNA fragments was drawn on a microarray by spotting 4 oligonucleotides according to the image pattern (the oligonucleotides were identical to the oligonucleotide later hybridized to the array, except for increasing number of mismatches, corresponding to different shades of grey in the black and white image) (courtesy of Thomas Albert, NimbleGen Systems). Brief Communications p903, 907, Article p931, News and Views p891

Volume 4 Issue 11

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Editorial

  • In the context of this month's global theme on poverty and human development, we are turning the spotlight to diagnostic methods—more specifically, tests for diagnosing infectious diseases in poverty-stricken areas.

    Editorial

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Correspondence

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Research Highlights

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Commentary

  • Research performed where epidemics hit the hardest is necessary to bring solutions to the major health crises that plague poverty-stricken areas. Far from being limited to these areas, 'research in situ' can benefit health management worldwide. There are pressing technological needs to be addressed in order to facilitate such research.

    • Robert M Grant
    Commentary
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News & Views

  • An aspirin-modulated gene expression control circuit provides a powerful method to regulate expression of bacterial genes inside an infected host. This should provide a safe and easy way to study host-pathogen interactions, and may have direct therapeutic applications.

    • Ohad Gal-Mor
    • B Brett Finlay
    News & Views
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Review Article

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Brief Communication

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Article

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Protocol

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Technology Feature

  • Scientists may have finally developed the techniques to reconstruct complete wiring diagrams for the neuronal circuitry of the human brain. Nathan Blow reports.

    • Nathan Blow
    Technology Feature
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Advertising Feature: Application Note

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