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Brief Communication
Nature Methods 4, 927–929 (1 November 2007) | doi:10.1038/nmeth1112
A monoclonal antibody for G protein|[ndash]|coupled receptor crystallography
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Abstract
G protein–coupled receptors (GPCRs) constitute the largest family of signaling proteins in mammals, mediating responses to hormones, neurotransmitters, and senses of sight, smell and taste. Mechanistic insight into GPCR signal transduction is limited by a paucity of high-resolution structural information.
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