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Nature Methods - 4, 828 - 833 (2007)
Published online: 27 September 2007; | doi:10.1038/nmeth1094

MALDI imaging mass spectrometry: molecular snapshots of biochemical systems

Dale S Cornett, Michelle L Reyzer, Pierre Chaurand & Richard M Caprioli

 
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Figure 1. General overview of MALDI-IMS.
(a) Fresh section cut from sample tissue (shown here, mouse brain). (b) Mounted section after matrix application using a robotic picoliter volume spotter. (c) Partial series of mass spectra collected along one row of coordinates (x axis). (d) Three-dimensional volumetric plot of complete dataset with selected m/z 'slices' or ion images. Principal axes are x, y and m/z. Color of each voxel is determined by ion intensity.

 
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