Mass spectrometry has been rapidly maturing as the core technology at the heart of proteomics. The application of these powerful methods to the study of human diseases and their translation to the clinic, however, has been beset with unique challenges.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency
Scientific Reports Open Access 30 January 2017
-
Construction of a high-performance magnetic enzyme nanosystem for rapid tryptic digestion
Scientific Reports Open Access 06 November 2014
-
A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine
BMC Medical Informatics and Decision Making Open Access 23 March 2009
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Petricoin, E., Wulfkuhle, J., Espina, V. & Liotta, L.A. J. Proteome Res. 3, 209–217 (2004).
Conrads, T.P., Hood, B.L., Petricoin, E.F., III, Liotta, L.A. & Veenstra, T.D. Expert Rev. Proteomics 2, 693–703 (2005).
Hanash, S. Nature 422, 226–232 (2003).
Massion, P.P. & Caprioli, R.M. J. Thorac. Oncol. 1, 1027–1039 (2006).
Marko-Varga, G. et al. J. Proteome Res. 6, 2925–2935 (2007).
Mayr, M. et al. Mol. Cell. Proteomics 5, 1853–1864 (2006).
Fu, Q. & Van Eyk, J.E. Expert Rev. Proteomics 3, 237–249 (2006).
Diamandis, E.P. J. Natl. Cancer Inst. 96, 353–356 (2004).
Karsan, A. et al. Clin. Chem. 51, 1525–1528 (2005).
Solassol, J. et al. Expert Rev. Proteomics 3, 311–320 (2006).
van der Merwe, D.E., Oikonomopoulou, K., Marshall, J. & Diamandis, E.P. Adv. Cancer Res. 96, 23–50 (2007).
deVera, I.E., Katz, J.E. & Agus, D.B. Clin. Adv. Hematol. Oncol. 4, 541–549 (2006).
Veenstra, T.D. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 847, 3–11 (2007).
Mischak, H. et al. Proteomics Clin. Appl. 1, 148–156 (2007).
Hernandez, P., Muller, M. & Appel, R.D. Mass Spectrom. Rev. 25, 235–254 (2006).
Barker, P.E. et al. Clin. Chem. 52, 1669–1674 (2006).
Prakash, A. et al. Mol. Cell. Proteomics, published online 27 July 2007 (doi:10.1074/mcp.M600470-MCP200).
Taylor, C.F. et al. OMICS 10, 145–151 (2006).
Zhang, H. et al. Mol. Cell. Proteomics 6, 64–71 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Beretta, L. Proteomics from the clinical perspective: many hopes and much debate. Nat Methods 4, 785–786 (2007). https://doi.org/10.1038/nmeth1007-785
Issue Date:
DOI: https://doi.org/10.1038/nmeth1007-785
This article is cited by
-
Identification of GIMAP7 and Rabl3 as Putative Biomarkers for Oral Squamous Cell Carcinoma Through Comparative Proteomic Approach
Pathology & Oncology Research (2020)
-
A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency
Scientific Reports (2017)
-
Construction of a high-performance magnetic enzyme nanosystem for rapid tryptic digestion
Scientific Reports (2014)
-
New Insight into Neurodegeneration: the Role of Proteomics
Molecular Neurobiology (2014)
-
Proteomic strategies and challenges in tumor metastasis research
Clinical & Experimental Metastasis (2010)
