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Journal home Advance online publication Current issue Archive Press releases Methagora Focuses Guide to authors Online submission Permissions For referees Free online issue Contact the journal Subscribe naturejobs For Advertisers work@npg naturereprints About this site For librarians Application notes   NPG Resources Nature Nature Biotechnology Nature Protocols Nature Genetics Nature Chemical Biology Nature Cell Biology Nature Neuroscience Nature Reviews Genetics Nature Reviews Molecular Cell Biology Nature Reviews Drug Discovery Nature Conferences NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications Application Note Nature Methods - 4, (2007) Advertising Feature Automated sorting of genetically engineered embryonic stem cells for generation of mouse models Although genetically modified mice have huge potential for the analysis of gene function, the creation of such mice via homologous recombination in embryonic stem cells (ESCs) is a tedious process. A combination of the CytoClone™ system from Evotec Technologies for cell selection with the ArteMice™ platform from Artemis Pharmaceuticals for rapid generation of genetically modified mouse models from engineered ESCs offers a fast and gentle way to isolate such cells. Authors Gunther Kauselmann1, Heidrun Kern1, Anne Klein-Vehne2, Torsten Müller3, Annette Pfennig3 & Branko Zevnik1 1  Artemis Pharmaceuticals GmbH, Neurather Ring 1, D-51063 Köln, Germany. 2  BiolytiQs GmbH & Co. KG, Merowingerplatz 1a, D-40225 Düsseldorf, Germany. 3  Evotec Technologies GmbH, Schnackenburgallee 114, D-22525 Hamburg, Germany. Correspondence should be addressed to Torsten Müller torsten.mueller@evotec-technologies.com  Top Abstract Previous | Next Table of contents Full text Download PDF Send to a friend Rights and permissions Order commercial reprints Save this link Figures & Tables Open Innovation Challenges Efficient Chromosome Doubling: Plant Cell Division Deadline: Jul 15 2009 Reward: $20,000 USD The Seeker is looking for an efficient chromosome doubling method in plants and in particular, metho... Plant Mitotic Arrest Agent & Protocol Deadline: Jul 15 2009 Reward: $20,000 USD The Seeker is looking for an efficient chromosome doubling method in plants, particularly with respe... More Challenges Powered by: nature jobs Scientist, Pathway Informatics Philip Morris International (PMI) Neuchâtel, Switzerland Synthetic Biology Indian Institute of Chemical Biology Kolkata India More science jobs Post a job for free Search buyers guide: ADVERTISEMENT

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