Nature Methods
- 4, 51 - 53 (2007)
Published online: 17 December 2006; | doi:10.1038/nmeth991
SILENCE: a new forward genetic technologyDavid J Banks & Kenneth A Bradley
Department of Microbiology, Immunology and Molecular Genetics, 609 Charles E. Young Dr. East, Molecular Sciences Building, University of California at Los Angeles (UCLA), Los Angeles, California 90095, USA.
Correspondence should be addressed to Kenneth A Bradley kbradley@microbio.ucla.edu Silencing induced by long terminal repeat (LTR)–encoded cis-acting response element, termed SILENCE, is a forward genetic system that allows for conditional, epigenetic control of host-gene transcription. This new research tool is independent of gene mutation or disruption, does not require complementation, and conditional gene repression appears complete at the level of protein function. SILENCE functions in hypodiploid cells and is a platform technology with broad applications in gene discovery.
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