Nature Methods
- 4, 20 - 21 (2007)
doi:10.1038/nmeth0107-20
From cryo-EM, multiple protein structures in one shotFred J Sigworth
Fred J. Sigworth is in the Departments of Cellular and Molecular Physiology and Biomedical Engineering, Yale University, New Haven, Connecticut, USA. fred.sigworth@yale.edu
A new maximum likelihood–based algorithm allows cryo-EM structure determination of macromolecular complexes even when conformational heterogeneity is present.
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