 | Figure 1
Nature Methods
- 3, 872 - 873 (2006)
doi:10.1038/nmeth1106-872a
Genomics Story of C'sVeronique Kiermer | | | | Figure 1. The 3C method captures physical associations between distal genomic regions using cross-linking followed by restriction enzyme (RE) digestion and ligation (1), then cross-link reversal (2).
A 3C library can now be copied and amplified into a 5C library, by multiplex hybridization of 5C primers (3) and ligation-mediated amplification (4). Adapted from Dotsie et al., 2006.
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