 | Figure 1
Nature Methods
- 3, 871 (2006)
doi:10.1038/nmeth1106-871
Protein Biochemistry A protein alternative to RNAiDaniel Evanko | | | | Figure 1. Ligand-dependent targeted protein elimination using a destabilization domain.
A small destabilization domain (green) is fused to a target protein of interest (red). The small molecule Shield-1 (pink) stabilizes the destabilization domain, protecting it from degradation. But when the molecule is removed, the entire fusion protein is rapidly degraded.
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