Herpesviruses throw a curve ball: new insights into microRNA biogenesis and evolution
Joel R Neilson
& Phillip A Sharp
Joel R. Neilson and Phillip A. Sharp are at the Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Correspondence should be addressed to Phillip A Sharp sharppa@mit.edu
Validation and comparison of previously unknown microRNA genes in related herpesviruses yielded several surprises, most notably in regard to viral evolution and microRNA biogenesis. An explosion of literature has recently appeared describing the identification and mechanism of action of microRNAs (miRNAs)—small RNA regulators of gene expression in plant and animal cells.
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