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Nature Methods 2, 817 - 824 (2005)
Published online: 21 October 2005; | doi:10.1038/nmeth807

Glycomics: an integrated systems approach to structure-function relationships of glycans

Rahul Raman, S Raguram, Ganesh Venkataraman, James C Paulson & Ram Sasisekharan

 
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Figure 1. Chemical diversity of glycans.
(a) Different classes of glycans in the symbol nomenclature developed as a collaborative effort to homogenize glycan representation. Directionality is from nonreducing end at the top to the reducing end at the bottom with the arrows indicating the extension at the nonreducing end. Linkages between monosaccharides contain the anomeric configuration of the monosaccharide (a, alpha and b, beta) and the oxygen atom in the reducing end monosaccharide to which it is linked to. "/" is used to represent either-or case (b3/4 means b3 or b4). In the case of complex N-linked glycans, the common terminal motifs attached to Gal are shown in a dotted box. Abbreviations HS, CS and DS correspond to heparin or heparin sulfate, chondroitin sulfate and dermatan sulfates, respectively.

 
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