Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Illuminating gap junctions

An imaging method termed LAMP, based on a newly described photo-activatable fluorophore, promises to illuminate how gap junctions mediate intercellular coupling.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Diagram of a gap junction complex under investigation by the LAMP method.

References

  1. Dankin, K., Zhao, Y. & Li, W.-H. Nat. Methods 2, 55–62 (2005).

  2. Stewart, W.W. Nature 292, 17–21 (1981).

    Article  CAS  Google Scholar 

  3. Suter, S. et al. Fundam. Appl. Toxicol. 9, 785–794 (1987).

    Article  CAS  Google Scholar 

  4. Chanson, M., Orci, L. & Meda, P. Am. J. Physiol. 261, G28–G36 (1991).

    CAS  PubMed  Google Scholar 

  5. Leybaert, L. & Sanderson, M.J. Methods Mol. Biol. 154, 407–430 (2001).

    CAS  PubMed  Google Scholar 

  6. Pitts, J.D. Bioessays 201, 1047–1051 (1998).

    Google Scholar 

  7. Spray, D.C. & Scemes, E. in pH and Brain Function (eds. Kaila, K. & Ransom, B.R.) 477–489 (Academic Press, New York, 1998).

    Google Scholar 

  8. Peracchia, C. Biochim. Biophys. Acta 1662, 61–80 (2004).

    Article  CAS  Google Scholar 

  9. Pereda, A.E. et al. Proc. Natl. Acad. Sci. USA 95, 13272–13277 (1998).

    Article  CAS  Google Scholar 

  10. De Pina-Benabou, M.H. et al. J. Neurosci. 21, 6635–6643 (2001).

    Article  CAS  Google Scholar 

  11. Song, X. et al. Glia advance online publication, 11 November 2004 (10.1002/glia.20128).

  12. Duffy, H.S., Delmar, M. & Spray, D.C. J. Physiol. Paris 96, 243–249 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spray, D. Illuminating gap junctions. Nat Methods 2, 12–14 (2005). https://doi.org/10.1038/nmeth0105-12

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth0105-12

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing