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Stylistic rendering of an array of nanopores sequencing single RNA molecules. Drawn by Peter Inkpen, iemedia solutions and adapted by Erin Dewalt, SpringerNature. p201
The combination of photoactivatable fluorescent markers with single-cell RNA-seq allows transcriptome analysis of cells from specific tissue locations.
This Perspective reviews nanoscopy via stimulated emission depletion (STED), focusing on challenges for biologists and how technical advances are helping to meet these challenges.
Chimeric receptors expressed on the surface of antigen-presenting cells enable the uptake of cancer-cell-derived extracellular vesicles and the display of tumor antigens.
A twist on a common method used for enriching phosphorylated peptides for mass spectrometry-based proteomics analysis now reveals previously undetected and widespread histidine phosphorylation in Escherichia coli.
An iterative structure factor retrieval algorithm allows electron densities to be directly calculated from solution scattering data, avoiding assumptions that limit modeling algorithms.
Direct sequencing of RNA molecules in real time using nanopores allows for the detection of splice variants and hold promises for profiling RNA modifications.
Labeling newly transcribed RNA with 5-ethynyluridine and adding biotin via click chemistry allows the analysis of the proteome bound to the various RNA species, including nascent RNA.
