Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Synthetic human proteomes for accelerating protein research

The generation of synthetic human proteomes and future derived tools will expand knowledge in protein biology.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schema followed in the highlighted publications to achieve complete characterization of the human proteome.

Marina Corral Spence/Springer Nature

References

  1. Nagaraj, N. et al. Mol. Cell. Proteomics 11, M111.013722 (2012).

    Article  Google Scholar 

  2. Zolg, D.P. et al. Nat. Methods 14, 259–262 (2017).

    Article  CAS  Google Scholar 

  3. Matsumoto, M. et al. Nat. Methods 14, 251–258 (2017).

    Article  CAS  Google Scholar 

  4. Kusebauch, U. et al. Cell 166, 766–778 (2016).

    Article  CAS  Google Scholar 

  5. Griss, J. et al. Nat. Methods 13, 651–656 (2016).

    Article  CAS  Google Scholar 

  6. Audain, E. et al. J. Proteomics 150, 170–182 (2017).

    Article  CAS  Google Scholar 

  7. Anonymous. Nat. Methods 10, 1 (2013).

  8. Picotti, P. & Aebersold, R. Nat. Methods 9, 555–566 (2012).

    Article  CAS  Google Scholar 

  9. Smith, L.M., Kelleher, N.L. & Consortium for Top Down Proteomics Nat. Methods 10, 186–187 (2013).

    Article  CAS  Google Scholar 

  10. Picotti, P. et al. Nature 494, 266–270 (2013).

    Article  CAS  Google Scholar 

  11. Schubert, O.T. et al. Cell Host Microbe 13, 602–612 (2013).

    Article  CAS  Google Scholar 

  12. Perez-Riverol, Y., Alpi, E., Wang, R., Hermjakob, H. & Vizcaíno, J.A. Proteomics 15, 930–949 (2015).

    Article  CAS  Google Scholar 

  13. Giansanti, P., Tsiatsiani, L., Low, T.Y. & Heck, A.J. Nat. Protoc. 11, 993–1006 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Juan Antonio Vizcaíno.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Perez-Riverol, Y., Vizcaíno, J. Synthetic human proteomes for accelerating protein research. Nat Methods 14, 240–242 (2017). https://doi.org/10.1038/nmeth.4191

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth.4191

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research