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Reversible RNA modifications in meiosis and pluripotency

Nature Methods volume 14, pages 18–22 (2017)Cite this article

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Abstract

Post-transcriptional RNA modifications were discovered several decades ago, but the reversible nature of RNA modifications has only recently been discovered. Owing to technological advances, knowledge of epitranscriptomic marks and their writers, readers and erasers has recently advanced tremendously. Here we focus on the roles of the dynamic methylation and demethylation of internal adenosines in mRNA in germ cells and pluripotent stem cells.

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Figure 1: General aspects of eukaryotic meiosis.
Figure 2: Dynamic m6A modifications at single-cell resolution.

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Acknowledgements

The writing of this Commentary was supported by the Oslo University Hospital, the Norwegian Cancer Society and the Norwegian Research Council.

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Authors and Affiliations

  1. Department of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Arne Klungland, John Arne Dahl & Adam Filipczyk

  2. Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

    Arne Klungland

  3. Norwegian Center for Stem Cell Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Arne Klungland & Adam Filipczyk

  4. Department of Gynecology, Section for Reproductive Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    Gareth Greggains & Peter Fedorcsak

Authors
  1. Arne Klungland
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  2. John Arne Dahl
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  3. Gareth Greggains
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  4. Peter Fedorcsak
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  5. Adam Filipczyk
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Correspondence to Arne Klungland.

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Klungland, A., Dahl, J., Greggains, G. et al. Reversible RNA modifications in meiosis and pluripotency. Nat Methods 14, 18–22 (2017). https://doi.org/10.1038/nmeth.4111

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