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Volume 13 Issue 11, November 2016

Confocal image of a four-day-old zebrafish embryo (10× objective) stained for markers of basal stem cells (green), surface epithelial cells (red) and all nuclei (blue). Image acquired by Oscar Ruiz in the laboratory of George Eisenhoffer at MD Anderson Cancer Center. Winner of the 2016 Nikon Small World photomicrography contest (reprinted with permission from O.R. and G.E.; image provided by Nikon).

Editorial

  • Reasoned, skeptical debate is the lifeblood of science. Its practitioners necessarily sit at the same table with others who disagree with them. This cannot be said of political discourse in America today.

    Editorial

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This Month

  • A chemist who illuminated biology.

    • Erik A Rodriguez
    • Nathan C Shaner
    • Robert E Campbell
    This Month
  • Appeal to intuition when making value judgments

    • Martin Krzywinski
    This Month
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Correspondence

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Research Highlights

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Methods in Brief

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Tools in Brief

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Research Highlights

  • The discovery of two distinct endonuclease activities in the C2c2 protein explains how template RNAs are processed in type VI CRISPR systems and enables the development of a sensitive RNA detection system.

    • Richard Pattison
    Research Highlights
  • Oxford scientists unleash radical chemistry to explore novel protein activities through synthetic post-translational modifications.

    • Stéphane Larochelle
    Research Highlights
  • In the mouse brain, researchers use sequencing to map long-range neuronal projections...a lot of projections.

    • Tal Nawy
    Research Highlights
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Technology Feature

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News & Views

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Brief Communication

  • The enzyme subtiligase can be used to catalyze expressed protein ligation of proteins of interest with peptides lacking an N-terminal cysteine. This enables the analysis of protein modifications in the context of the native primary sequence.

    • Samuel H Henager
    • Nam Chu
    • Philip A Cole
    Brief Communication
  • Nicking mutagenesis is a streamlined protocol for plasmid-based single-pot comprehensive saturation mutagenesis.

    • Emily E Wrenbeck
    • Justin R Klesmith
    • Timothy A Whitehead
    Brief Communication
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Article

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